gansk兵临城下
截至到目前为止，在国内外核心期刊发表学术论文 50 余篇 ( 第一作者 ), 其中 SCI 收录 20 余篇。以第一或通讯作者发表的主要代表论文（均为 SCI 收录）有：1. Antibody directed lentiviral mediated double suicide gene therapy in MUC-1 positive leukemia in vitro and in vivo. Cell Transplant 2011(In Press)2. PPARγ Agonist Suppresses TLR4 Expression and TNF-α Production in LPS Stimulated Monocyte Leukemia Cells. Cell Biochem Biophys . 2010 Nov 23. [Epub ahead of print] ( 通讯作者 ) 。3. Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro. Annals of Hematology 2010; 89(5):1089–1097. （通讯作者）4. Down-Regulation of Telomerase Activity and Activation of Caspase Are Responsible for Tanshinone I-Induced Apoptosis in Monocyte Leukemia Cells. International Journal of Molecular Sciences 2010; 11(5): . Activation ofperoxisome proliferator-activatedreceptor-gamma induces apoptosis on acute promyelocyti leukemia cells via downregulation of XIAP. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2009; 24(5): Proliferator-ActivatedReceptor γ (PPAR-γ) Agonist Rosiglitazone (RGZ) Inhibits HL-60 Cell Growth by Induction of Apoptosis. Lab Medicine 2009; 40(5):. Tanshinone IIA inhibits leukemia THP-1 cell growth by induction of apoptosis. Oncology Reports 2009; 21(3): Proliferator-ActivatedReceptor-g Agonist Rosiglitazone–Induced Apoptosis in Leukemia K562 Cells and Its Mechanisms of Action. International Journal of Toxicology 2009; 28(2):. Ponicidin Inhibits Monocytic Leukemia Cell Growth by Induction of Apoptosis. International Journal of Molecular Sciences 2008 ; 9(11) : . Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved inperoxisome proliferator-activatedreceptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. Annals of Hematology 2007;86 (3):. Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro. Journal of Biomedical Science 2006; 13(12):813–. Antiproliferation Effects of Oridonin on HPB-ALL Cells and Its Mechanisms of Action. American Journal of Hematology 2006; 81(2):86–. Ponicidin, an Ent-Kaurane Diterpenoid Derived from a Constituent of the Herbal Supplement PC-SPES, Rabdosia rubescens , Induces Apoptosis by Activation of Caspase-3 and Mitochondrial Events in Lung Cancer Cells In Vitro. Cancer Investigation 2006; 24(2):136–. Expression of survivin and bax/bcl -2 in peroxisome proliferator activated receptor-{gamma} ligands induces apoptosis on human myeloid leukemia cells in vitro . Annals of Oncology 2005; 16(3):. Peroxisome proliferator activated receptor- ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells. Cancer Chemotherapy and Pharmacology 2005;56(4):. Oridonin-induced apoptosis in leukemia K562 cells and its mechanism. Neoplasma 2005;52 (3):. Antiproliferation effects of ponicidin on human myeloid leukemia cells in vitro . Oncology Reports 2005; 13 (4):. Apoptotic effect of oridonin on NB4 cells and its mechanism. Leukemia & Lymphoma 2005; 46 (4): . Antiproliferation effects of oridonin on HL-60 cells. Annals of Hematology 2004; 83(11):. Anti-proliferative effects of oridonin on SPC-A-1 cells and its mechanism of action. Journal of International Medical Research 2004; 32 (6): . Oridonin Inhibit Cell Growth by Induction of Apoptosis on Human Carcinoma BEL7402 Cells. Hepatology Research . 2006;35(2) . Oridonin-induced apoptosis of Jurkat cells and its mechanism. Comparative Pathology. 2004;13(2): 65-69.
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(注*者为通讯作者)1. 李进,胡宏远,赵亚南.正常妊娠血管紧张素转换酶的变化.笫二军医大学学报, 1989,10(5) :. Jin Li,Yanan Zhao,Hongyuan influence of normotensive pregnancy on serum angiotensin converting enzyme activity. J Med Coll PLA 1990,5(1):. ．李进,胡宏远,赵亚南.妊高症血管紧张素转换酶的活性.中华妇产科杂志, 1991,26(1):. 李进,胡宏远.血管紧张素转换酶与妊高症.国外医学妇产科分册1991, (6):. 李进,赵亚南,苗志军.盆腔动脉栓塞化疗后组织耐受性研究.中华妇产科杂志, 1993,28(1) :．Jin Li, Hongyuan Hu, Yanan Zhao. Angiotensin converting enzyme activity in pregnancy induced Obstet Invest 1992,3(3):．Jin Li, Ya-nan Zhao,Zi-jun Miao. Tissue tolerance to pelvic TACE with cisplatin-lipiodol suspension. Gynecol Oncol 1993,50:. 李进,刘玉兰,沙金燕.肿瘤坏死因子与干扰素协同抗卵巢癌作用的研究.中华妇产科杂志,1994,29(11):. 宋岩峰,赵亚南,李进,等.淋巴因子激活杀伤的快速激活及其临床应用.中华妇产科杂志,1994,9(6):．赵亚南,陈有梅,李进，等.微波治疗生殖器尖锐湿疣的疗效.中国光电医学, 1994,3(1):. 李进,惠宁,朱玲仙,等.肿瘤坏死因子、干扰素与化疗药物联合作用在体外对卵巢癌细胞株生长的影响.中华肿瘤杂志, 1995,17(6):. 李进,孔宪涛,钱其军.ICE诱导肿瘤细胞的凋亡.中国肿瘤生物治疗杂志, 1996,3(4):. 李进,孔宪涛,赵亚南.肿瘤坏死因子诱导肿瘤细胞产生氧自由基.笫二军医大学学报, 1998,19(1):.袁巧玲,李进,赵亚南.肿瘤坏死因子、更生霉素、干扰素联合应用对卵巢癌裸鼠模型的协同作用.现代妇产科进展, 1998,7（1）：.惠宁,李进,戎霖.肿瘤坏死因子、干扰素与化疗药物对肿瘤细胞超微结构的影响.笫二军医大学学报, 1998,19(3):. Jin Li, Xiantao Kong,Qijun influence of ICE expression on the phenotype of overian cancer J Biother Cancer,1999, 2（2）:. 李进,孔宪涛,钱其军.ICE凋亡基因逆病毒载体的构建及对卵巢癌生物学特性的影响.中华妇产科杂志, 1999,34(2):.李进,田建民,王昭梅，等.盆腔动脉栓塞化疗治疗妇科肿瘤.笫二军医大学学报2000,21（2）．路红社, 李进, 王雅杰, 薛春燕, 查名宝肿瘤标志物CA242对恶性肿瘤辅助诊断的价值第二军医大学学报, 2000年 11期20. Jin Li, Yin Sun, Alan Garen*. Immunization and immunotherapy for cancers involving infection by a human papillomavirus in a mouse mode. PNAS, 99(25):16232–16236;.张文，胡夕春，陆洪芬，施达仁，李进.甲磺酸伊马替尼治疗不能切除和/或转移的胃肠道间质瘤的临床分析。中国癌症杂志2003，13（5）：448－452。22.胡夕春, 李进.乳腺癌内科治疗进展.现代实用医学, 2004年 05期23.李进， 大肠癌分子靶向治疗。中国癌症杂志2004，14（5）：415－41824.李进、王坤、徐崇锐。Erlotinib治疗晚期非小细胞肺癌的综合研究。循证医学。2004，4（4）199－20225.李进，孙颖，Masako chen，李锋，Alan Garen。 VII因子-SEA融合蛋白的抗肿瘤效果。中华肿瘤杂志, 2005,27(8):.胡夕春、郭海宜、扬新苗、李进。乳腺癌肝转移患者预后的多因素分析。中国癌症杂志2005，15（5）：438－44127.李 进, 左云霞, 陈治宇,等。92例晚期大肠癌生存分析。临床肿瘤学杂志 2005，10（6）23-2628.李 进, 张文, 陈治宇,等。复发转移性结直肠癌的化疗进展。实用肿瘤杂志 2005，20（6）．王佳蕾，洪小南，唐惟瑜，郭晔，李进*。吉西他滨联合顺铂治疗头颈部癌52例分析。中华肿瘤杂志, 2005,27(9):．胡夕春, 郭海宜, 赵欣闵, 王中华, 杨新苗, 刘向锦, 李进* 。丝裂霉素加顺铂治疗难治性晚期乳腺癌. 临床肿瘤学杂志 2006; 11(8):．李进。复发转移结直肠癌的化疗进展《BMJ中文版》2006，9：增刊：71-76。32．李进。单克隆抗体联合依立替康在结直肠癌治疗中的应用。《中华肿瘤杂志》, 2006,28(10):. Biyun Wang, Jiade J Lu, Xuejun Ma, Ye Guo, Hongfen Lu, Xiaonan Hong, Jin Li*. Combined chemotherapy and external beam radiation for stage IE and IIE natural killer T-cell lymphoma of nasal cavity. Leukemia and Lymphoma, 48(2):396-402: ．于惠，洪小南，李进*，彭丽萍.侵袭性非霍奇金淋巴瘤的预后分析。 中华肿瘤杂志. 2007 Jun;29(6):461-3。35. Guo Y, Lu JJ, Ma X, Wang B, Hong X, Li X, Li J*.Combined chemoradiation for the management of nasal natural killer (NK)/T-cell lymphoma: Elucidating the significance of systemic Oncol. 2008 Jan;44(1):. Jun Cao, Yunxia ZUO, Fangfang Lv, Zhiyu Chen, Jin LI.* Primary Small Intestinal Malignant Tumors- Survival analysis of 48 postoperative patients. J Clin Gastroenterol, 2008 Feb；42（2）：. Wang J, Li J*, Hong X, Tang W, Hu X, Wang B, Gu Y. Retrospective case series of gemcitabine plus cisplatin in the treatment of recurrent and metastatic nasopharyngeal Oncol. 2008 May;44(5): B, Zhang W, Hong X, Guo Y, Li J*. Phase I dose-escalating study of 24-h continuous infusion of 5-fluorouracil in combination with weekly docetaxel and cisplatin in patients with advanced gastric cancer. Cancer Chemother Pharmacol. 63：2 (2009), . Wu X, Li Z, Yao M, Wang H, Qu S, Chen X, Li J, Sun Y, Xu Y, Gu J. Identification and characterization of a novel peptide ligand of Tie2 for targeting gene therapy. Acta Biochim Biophys Sin. 2008 Mar;40(3):. Yang X, Cai Y, Zhao X, Wang Z, Hong X, Shen Z, Ou Z, Li J, Hu X. Biweekly docetaxel-containing chemotherapy may be the optimal schedule. Anti-Cancer Drugs. 2008;19(4):. Guo HY, Zhao XM, Li J, Hu XC. Primary non-Hodgkin’s lymphoma of the breast: eight-year follow-up experience. Int J Hematol . Li J*, Yin J, Zhu X, Liu Y, Cao J, Lu F, Zuo Y. Phase I dose-escalating study of S-1 in combination with oxaliplatin for patients with advanced and/or metastatic colorectal cancer. Anticancer Drugs. 2008 Aug;19(7):. Lei N, Shen FB, Chang JH, Wang L, Li H, Yang C, Li J*, Yu oncolytic adenovirus expressing granulocyte macrophage colony-stimulating factor shows improved specificity and efficacy for treating human solid Gene Ther. 2009;16(1):. Gui XH, Qiu LX, Zhang HF, Zhang DP, Zhong WZ, Li J*, Xiao 309 T/G polymorphism is associated with lung cancer risk among J Cancer. 2009 Mar . Qiu LX, Shi J, Yuan H, Jiang X, Xue K, Pan HF, Li J*, Zheng -1,377 G/A polymorphism is associated with cancer susceptibility: evidence from 10,564 cases and 12,075 Genet. 2009 May;125(4):431-5. Epub 2009 Feb . Chang J, Zhao X, Wu X, Guo Y, Guo H, Cao J, Guo Y, Lou D, Yu D, Li J*. A Phase I study of KH901, a conditionally replicating granulocyte-macrophage colony-stimulating factor: armed oncolytic adenovirus for the treatment of head and neck cancers. Cancer Biol Ther. 2009 Apr;8(8):676-82.
柏拉图ing
1988年毕业于北京医科大学（现北京大学医学部）医学系，1991年、1997年获苏州医学院（现苏州大学医学院）硕士、博士学位，师从中国工程院院士阮长耿教授长。1997年6-7月，英国皇家自由医院大规模单抗制备技术，1997年12月-1998年11月法国南特大学医院中心博士后，开展多发性骨髓瘤的荧光原位杂交研究。1991年7月-2001年3月，苏州大学附属第一医院血液科、江苏省血液研究所工作，历任医师、主治医师、副主任医师、血液科副主任、血研所副所长，2001年4月始在江苏省人民医院工作，2007年12月-2008年3月组团德国乌尔姆大学专项进修慢性淋巴细胞白血病基础与临床研究专业领域： 一直从事血液病的临床及科研工作，擅长利用多参数流式细胞术、荧光原位杂交技术及分子生物学技术对恶性血液病诊断分型、预后判断、病情监测，并根据患者的临床生物学特征采取个体化治疗策略。据国内领先水平。目前主要研究方向为淋巴增殖性疾病，主要开展慢性淋巴细胞白血病诊断、鉴别诊断、预后相关因素、发病机制及临床治疗研究。起草了《中国慢性淋巴细胞白血病诊断与治疗专家共识》（中华血液学杂志2010年第2期）。在亚洲居于领先水平。 学术团体任职情况： 中华医学会血液学分会委员、中国实验血液学会委员、中国抗癌协会血液学分会委员、江苏省血液学会副主任委员、南京市血液学会主任委员。中华血液学杂志、中国实验血液学杂志、国际输血及血液学杂志、南京医科大学学报、白血病淋巴瘤等5种杂志的编委。 近 五年在国内外核心期刊上发表学术论文情况： 论文题目刊物名称刊物国家收录情况卷期排名 The investigation of mutation and single nucleotide polymorphism of receptor tyrosine kinases and downstream scaffold molecules in acute myeloid leukemia Leuk Lymphoma 国外 SCI 2006,47⑿：2610-6 通讯 Effect of low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor priming (CAG regimen) on the outcome of elderly patients with acute myeloid leukemia Leuk Res 国外 SCI 2007,31⑽：1383-8 通讯 Interphase fluorescence in situ hybridization detection of cytogenetic abnormalities in B-cell chronic lymphocytic leukemia Int J Hematol 国外 SCI 2007,85⑸：430-6 通讯 MicroRNA gene expression in malignant lymphoproliferative disorders Chin Med J 国内 SCI 2007,120⑾：996-9 通讯 The prognostic evaluation of CLLU1 expression levels in 50 Chinese patients with chronic lymphocytic leukemia Leuk Lymphoma 国外 SCI 2007,48⑼：1785-92 通讯 Prognostic significance of ATM and TP53 deletions in Chinese patients with chronic lymphocytic leukemia Leuk Res 国外 SCI 2008,32⑺：1071-7 通讯 Outcome of treatment with Hyper-CVAD regimen in Chinese patients with acute lymphocytic leukemia Leuk Res 国外 SCI 2008,32⑹：930-5 通讯 Successful application of nonmyeloablative stem cell transplantation for paroxysmal nocturnal hemoglobinuria Chin Med J 国内 SCI 2007,120（22）：2056-8 通讯 JAK2 V617F patients with essential thrombocythemia present with clinical features of polycythemia vera Leuk Lymphoma 国外 SCI 2008,49⑷：696-9 通讯 MPL W515L mutation in Chinese patients with myeloproliferative diseases Leuk Lymphoma 国外 SCI 2008,49⑸：955-8 通讯 Expression level of lipoprotein lipase in Chinese patients with chronic lymphocytic leukemia and its correlation with other prognostic factors Int J Lab Hematol 国外 SCI 2009,31⑸：552-9. 通讯 Trisomy 22 as the sole abnormality is an important marker for the diagnosis of acute myeloid leukemia with inversion 16 Onkologie 国外 SCI 2008,31（8-9）：440-4 通讯 An analysis of complex chromosomal aberrations in seven cases of myelodysplastic syndromes by M-FISH and whole chromosome painting Int J Hematol 国外 SCI 2008,88⑷：369-73 通讯 An update of molecular pathogenesis and diagnosis of myeloproliferative disorders in the JAK2 era Chin Med J 国内 SCI 2008,20;121⒅：1838-42 通讯 The negative prognostic impact of derivative 9 deletions in patients who received hydroxyurea treatment for chronic myelogenous leukemia in the chronic phase Onkologie 国外 SCI 2008,31⑾：585-9 第一 CD38 as a prognostic factor in Chinese patients with chronic lymphocytic leukaemia Leuk Res 国外 SCI 2009,33⑵：237-43 通讯 Nonhematological autoimmunity (glomerulosclerosis,paraneoplastic pemphigus and paraneoplastic neurological syndrome) in a patient with chronic lymphocytic leukemia: diagnosis,prognosis and managemen Leuk Res 国外 SCI 2009,33⑶：500-5 通讯 Bortezomib in combination with dexamethasone for a young multiple myeloma with t（8;14） Leuk Res 国外 SCI 2009,33⑷：584-6 第一 Flow cytometric assay of phosphotyrosine levels in Bcr-Abl-positive chronic myelogenous leukemias: a potential prognostic marker Ann Hematol 国外 SCI 2009,88⑴：29-36 通讯 Clinical features and outcome of Chinese patients with monoclonal B-cell lymphocytosis Leuk Res 国外 SCI 2009,33⑿：1619-22. 通讯 The decrease of JAK2 V617F allele burden in leukemia transformation of an elderly patient with myelofibrosis Leuk Res 国外 SCI 2009,33⑻：e116-118 通讯 Molecular cytogenetic aberrations in 21 Chinese patients with plasma cell leukemia Int J Lab Hematol 国外 SCI 2009,31⑶：338-343 通讯 GATA-2 L359 V mutation is exclusively associated with CML progression but not other hematological malignancies and GATA-2 P250A is a novel single nucleotide polymorphism Leuk Res 国外 SCI 2009,33⑻：1141-1143. 通讯 Trisomy 8 in two newly diagnosed Chinese patients with chronic lymphocytic leukemia Cancer Genet Cytogenet 国外 SCI 2009,192⑵：79-81 通讯 The negative prognostic significance of positive direct antiglobulin test in Chinese patients with chronic lymphocytic leukemia Leuk Lymphoma 国外 SCI 2009,50⑼：1482-7 通讯 Serum thymidine kinase 1 concentration in Chinese patients with chronic lymphocytic leukemia and its correlation with other prognostic factors Int J Hematol 国外 SCI 2009,90⑵：205-211 通讯 Cotransplantation of HLA-identical mesenchymal stem cells and hematopoietic stem cells in Chinese patients with hematologic diseases Int J Lab Hematol 国内 SCI 2009 Jul 28. [Epub ahead of print] 通讯 Multiplex fluorescence in situ hybridization in identifying chromosome involvement of complex karyotypes in de novo myelodysplastic syndromes and acute myeloid leukemia Int J Lab Hematol 国内 SCI 2010,32（1 Pt 1）：e86-95. 通讯 The analysis of JAK2 and MPL mutations and JAK2 single nucleotide polymorphisms in MPN patients by MassARRAY assay Int J Lab Hematol 国外 SCI 2010 Mar 23. [Epub ahead of print] 通讯
细胞生物学是生命科学领域的基础学科。其历史悠久，内容更新迅速，技术方法先进，并且发展活跃，适合进行双语教学。 教育部在2001年9月3日印发《关于加强高等学校本
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