医学论文翻译小组

你好，翻译为：“[Abstract] Objective: To compare ziprasidone and haloperidol in the treatment of schizophrenia in acute phase of the efficacy and side effects. Methods: Injection ziprasidone and haloperidol injection, the patients were randomly divided into 75 cases of ziprasidone group (n = 38) and with the haloperidol group (n = 37), for a period of five days of treatment . Respectively before and after treatment using Positive and Negative Syndrome Scale (PANSS), Clinical overall scale of India (CGI) and adverse reactions Scale (TESS) assessed the efficacy and adverse drug reactions. Pre-treatment determination of baseline ECG with QTc interval after treatment compared to baseline for more than 60ms for QTc interval prolongation ①, the treatment of cardiac rhythm during the medical examination found abnormal electrocardiogram monitoring in time. Results: Ziprasidone and haloperidol groups before and after treatment the total score and PANSS positive symptoms scale factor at a considerable reduction rate; CGI score to achieve a turn for the better and were more than 25 cases (), 26 cases of (); TESS evaluation of side effects occurred in 10 cases () 12 cases (). By T test no significant difference (P> ). Major group of ziprasidone alcohol side effects of insomnia, the main side effects of haloperidol group extrapyramidal reaction, but the ziprasidone group, 3 cases () of QTc interval prolongation, 2 cases () of cardiac rhythm disorders; haloperidol impact on the ECG for ventricular arrhythmia, was found significantly prolonged QTc interval. Conclusion: Ziprasidone injection with injection of haloperidol treatment of schizophrenia in acute phase of the effect of a considerable, but the group ziprasidone QTc interval on the heart and whether the impact of abnormal heart rate caused by a high degree of attention required.[Key words] haloperidol Ziprasidone in acute phase of schizophrenia”。